Objective-

Foot ulceration remains a major health problem for diabetic patients and has a major impact on cost of diabetes treatment. We tested a hyperspectral imaging technology that quantifies cutaneous tissue hemoglobin oxygenation and generated anatomically relevant tissue oxygenation maps to assess the healing potential of diabetic foot ulcers (DFU).

Research Design and Methods-

Prospective single arm blinded study that enrolled 66 patients with type 1 and 2 diabetes mellitus (DM) and followed them over a 24-week period. Clinical, medical and diabetes histories were collected. Transcutaneous oxygen tension was measured at the ankles. Superficial tissue oxyhemoglobin and deoxyhemoglobin were measured with hyperspectral imaging from intact tissue bordering the ulcer. A healing index, derived from oxyhemoglobin and deoxyhemoglobin values was used to assess the potential for healing.

Results-

Fifty-four patients with 73 ulcers completed the study; 54 ulcers healed while 19 ulcers did not heal at 24 weeks. When using the healing index to predict healing, the sensitivity was 80% (43/54), the specificity was 74% (14/19), and the positive predictive value was 90% (43/48). The sensitivity, specificity and positive predictive values increase to 86%, 88% and 96% respectively, when removing three false positive osteomyelitis cases and four false negative cases due to measurements on a callus. The results indicate that cutaneous tissue oxygenation correlate with wound healing in DM patients.

Conclusion-

Hyperspectral imaging of tissue oxyhemoglobin and deoxyhemoglobin may predict healing of DFUs with high sensitivity and specificity based on information obtained from a single visit.

Read more about EVALUATION OF DIABETIC FOOT ULCER HEALING WITH HYPERSPECTRAL IMAGING OF OXYHEMOGLOBIN AND DEOXYHEMOGLOBIN

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